Publications

Clinical outcomes of diabetic foot management with Circulat

Research Article
Clinical outcomes of diabetic foot management with Circulat
J. A. Olalde, M. Magarici, F. Amendola, O. del Castillo *, S. Gonzalez, A. Muhammad
Adaptogenic Medical Center, Caracas 1080, Venezuela
email: O. del Castillo (corpgov2004@yahoo.com)

*Correspondence to O. del Castillo, Adaptogenic Medical Center, Calle Luis de Camoens c/c Del Arenal, La Trinidad, Caracas 1080, Venezuela.

Keywords
diabetes • diabetic foot amputation • adaptogens • systemic

Abstract
Major and minor lower-extremity amputation is a common complication among diabetics. Various sources indicate diabetic foot ulcer prevalence at between 2.2% and 15% in diabetics. This study evaluates the efficacy and tolerance of a standardized plant extract combination, Circulat, developed for the prevention and treatment of severe manifestations of type 2 diabetes, such as necrotic damage of the foot. Thus, a retrospective cohort study was carried out in 174 patients treated with Circulat with diabetic foot grades D1-D3, according to The University of Texas Wound Classification System, in 50 medical centers, from 2004 to 2007. Circulat obtained 50.57% complete cure of diabetic foot, significant improvement in 37.9% and prevented amputation in 88.5% of the study's total population. The treatment was well tolerated. Four patients (2.3%) had slight gastrointestinal unrest which did not warrant suspension of treatment. Copyright © 2008 John Wiley & Sons, Ltd.
Received: 15 June 2007; Revised: 8 October 2007; Accepted: 12 November 2007

Phytotherapy Research: Analysis of effects of the herbal preparation circulat on gene expression levels in cultured human fibroblasts.

Publication date: May/18/07
Circulat is a systemic standardized plant extract formulation that was developed for the prevention of severe manifestations of type 2 diabetes such as necrotic damage of the plantar foot. With the aim of revealing the molecular mechanisms underlying Circulat's biological activity, the effects of Circulat treatment on gene expression levels were examined in the cultured human fibroblast cell line MRC-5 using Affymetrix oligonucleotide microarrays. The analysis identified 187 genes, the expression levels of which underwent significant changes upon Circulat treatment. These include four genes (IL6, HMGA1, SLC19A2 and C4A) that have been implicated previously in the development of diabetes. A large proportion of the identified genes are involved in energy metabolism, protein synthesis, glucose metabolism and signaling pathways. Synergistic action of the Circulat components has also been revealed. Prospective applications of microarray analysis in phytopharmacology are discussed. Copyright © 2007 John Wiley & Sons, Ltd.
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“ Evidence based Complementary and Alternative Medicine ( eCAM )”

Date: Vol 2, Num 4, Dec 2005

Recent past and even present successful naturalists and phytotherapeutic practitioners share a long and honorable tradition of knowledge and pride in the cure of illnesses, which goes back to written history and beyond.

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Discovery SALUD publishes Systemic Medicine results in Diabetes.

Publication date: Dec/21/06
In its last number, Discovery SALUD published an extensive news article on Systemic Medicine and the excellent results that one of its herbal formulas - Circulat- can obtain in the treatment of the diabetes and its complications.
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Dsalud is a Spanish magazine that publishes medical information without bias. It has a widespread reach and is distributed monthly in Spain , Portugal , Venezuela , Colombia , Peru , Ecuador and Guatemala.

After three years of treatment in thousands of patients a group of doctors has demonstrated that the ingestion of a phytomedicine formulation -denominated ‘Circulat' and elaborated with a selection of adaptogens- obtains remarkable improvements among those patients who are affected by diabetes and diabetic foot - avoiding the amputation in most cases and also acting in all type of circulatory ailments and ulcers of vascular origin. In diabetic foot the therapeutic success is more than 80%! This is verifiable through before and after photographic documentation -of the injuries- and corroborated by means of a Doppler echosonogram. This treatment is quick, noninvasive non traumatic and at a very low cost.